Neuroscience & Neurology
Irritable Bowel Syndrome Linked to Abnormal Brain Activity
Irritable bowel syndrome (IBS) affects 10 to 15 percent of the U.S. population, predominately women, and can produce severe abdominal pain, bloating, and changes in bowel habits. No physical abnormalities can be identified on examination, and patients are often left with suboptimal symptomatic treatments and the idea that the pain is “all in your head.”
Well, maybe it is.
A new study used magnetic resonance imaging (MRI) to detect differences in brain activity in IBS patients compared to healthy ones. When predictable, mild abdominal pain was stimulated in healthy women, MRI showed decreased activity in the insula, amygdala and brainstem, areas associated with emotion and pain. IBS patients did not show decreased activity in these areas, suggesting they are hard-wired to respond more strongly to pain than others.
The idea that the errors in the perception of pain are the underlying cause of IBS has been around a long time, but this is one of the first studies to demonstrated altered brain activity in the disease. Researchers hope that this information may lead to medications targeted at the brain centers or peripheral nerves responsible for the abnormal signaling.
Patients with IBS often feel left out in the cold. Current treatments for the symptoms of IBS only work temporarily and only in some patients. Many studies have demonstrated a link between anxiety, depression and IBS. Perhaps the link lies in an incorrect, hyperactive perception of pain and danger resulting in increased sensitivity to both emotional and physical pain.
I myself have a long history of abdominal pain that fails to respond to most treatments. I’ve undergone a battery of medical tests, all with no definitive results. IBS is a diagnosis of exclusion, given when all other ausative factors are eliminated as possibilities, so I know that my pain could easily be diagnosed as IBS. And yes, the pain is more frequent and more severe when I am anxious and stressed out, as it is for many women. But that doesn’t mean the pain isn’t real, and that doesn’t mean there isn’t a real organic cause. Even if I don’t have a tumor, or an ulcer, or something else in my belly causing me pain, maybe I just have I hyperactive amygdala, and maybe future researchers will learn how we can retrain or medicate the parts of our brain that are responsible for emotional responses to pain.
Reference
Berman S, Naliboff B et al. Reduced Brainstem Inhibition during Anticipated Pelvic Visceral Pain Correlates with Enhanced Brain Response to the Visceral Stimulus in Women with Irritable Bowel Syndrome. J. Neurosci. 2008 28: 349-359.
8 Comments/Trackbacks
dar
Pam Hampton
While I, a woman have SBS(short bowel syndrome)(only 12 inches of small intestine after a bowel resection). I live with the same symptoms as a person with IBS. In reading this article, I have to wonder if this is happening to my husband who is extremely Bi-Polar. He has been suffering from IBS for as long as he can remember. With the mood swings from depression to homicideal episodes. When his anziety (manic) is high, his IBS just rages. He’s mentally so down on himself at these times, the depression time is when it hits the hardest.
Thanks for the interesting article, we need to discuss this with his primary Dr as well as his phychiatrist. In connecting with the two, we may have the answer to all the tests that have came up negitave so far.
I appreciate your writing on this topic, which is important to many with pain and IBS. But your use of the pejorative phrase “it’s all in your head” – however well meaning in the context of the story – followed immediately by “Well, maybe it is” tends to reinforce the misconception shared by many that IBS is not a ‘real’ disorder but is, instead, as IBS suffers continue to hear over and over again, ‘all in your head.’ It would have been accurate and just as catchy to say, “Well, its not – but it is, at least in part, in your brain.”
Jan Patenaude, RD, CLT
Working with IBS patients has been my specialty are for the past 6 years. I must say, it’s in the gut, not in the head for most true IBS patients. I’ve been using a blood test called a Mediator Release Test to help identify trigger foods and chemicals. (Do you know ANYBODY with IBS that hasn’t identified that diet plays a role?)
Then, based on blood-test results, an individualized diet is set up. I’ve seen amazing results.
The president of the company I work with was an IBS cripple prior to finding out his triggers – that’s why he went to work for the company. He figured others shouldn’t have to suffer for 35 years, as he had, when there are better answers than trial and error. (He’s happy to share his story with anybody willing to listen. Does he still have IBS? Yes – Are symptoms controlled now – yes also.)
I’ve seen many lives restored, anxiety reduced, headaches relieved, etc. etc. As an RD since 1982, it’s the most exciting and rewarding work I’ve done since starting in the nutrition field.
There is so much research to show that it’s not “all in your head” – but there is certainly a relationship between mediators that can cross the blood-brain barrier and symptoms, so, yes, some of it is “in the head.”
Always happy to talk, privately if needed, with anybody. Would love to spread the word about the most effective diet therapy I’ve ever worked with!
travis
Irritable bowel syndrome, commonly referred to as IBS, is believed to be caused by the dysfunction of the muscles that control the gastrointestinal tract. It is also said that these muscle dysfunctions could be caused by the nerves which control the related organs of this tract.
The nervous control of the gastrointestinal tract is extremely complex. A system of nerves runs the full length of the gastrointestinal tract from the esophagus to the anus in the muscular walls of the organs. These nerves communicate with the nerves traveling to and from the spinal cord. Nerves within the spinal cord travel to and from the brain. Therefore, abnormal function of the nervous system in IBS may occur in a gastrointestinal muscular organ, the spinal cord, or the brain. The nervous system controlling the gastrointestinal organs, as with most other organs, contains sensory and motor nerves. Theses nerves continuously sense what is happening within the organs and relay this information to nerves in the organ’s wall. From there, information can be relayed to the spinal cord and brain. This information is received and processed in the organ’s wall, the spinal cord, or the brain. Then, based on this sensory input and the way the input is processed, responses are sent to the organ over the motor nerves. The most common motor responses in the intestine are contraction or relaxation of the muscle of the organ and secretion of fluid and/or mucus into the organ.
An IBS cartoon for you
http://pastexpiry.blogspot.com/2009/03/cartoon-irritable-bowel-syndrome-ibs.html
Past Expiry Cartoon LINK
Gail R Berger
I think that IBS can be best understood as emanating from cumulatively experienced neural responses to chronic stress, including neural responses in the CNS and neurohormone response (e.g. cortisol for negative feedback response to the initial generation of CRH and ACTH production). It is well founded in the research that environmental stress induces immediate alterations in brain activity and neurohormone response. Cumulatively and chronically experienced stress also produces later and chronic mind-body changes. The research on brain activity of later adult survivors with PTSD having histories of early childhood abuse provide a window to support this view.
So it is in one’s head (the neural response) and also in one’s body. It is also a response to prior stressful environmental experience, including those invoiving social interactions. Please reference the research of Bruce Naliboff and Doug Drossman. Doug Drossman on UNC has done a good deal of research with IBS patients, those having active symptoms and histories of child abuse and those with active symptoms without histories of child abuse. He was able to document different brain activity in both respective populations of patients to experimentally induced distress. The impact of prior stress, including those involving stress-filled social interactions, should not be underestimated.
Trackbacks
Leave a Reply
Saturday, March 13, 2010
- Religion - A "Natural" Phenomenon?
- Psychotropics and Youth, Part 1 - The Five Myths
- How Culture Shapes Our Mind and Brain
- Sex, Violence and The Male Warrior Hypothesis
- The Secret to Good Health – Listen to the Data
- If Herbal Medicine is Medicine, Shouldn't it be Treated as Such?
- Neurology, Neurosurgery, and Neuroscience Conferences for 2010
- Too Much Information?
- "I Feel Your Pain" - The Neural Basis of Empathy
- Income Inequality and Health Outcomes
- The Evolution of Depression
- Journal Retracts Autism Research
- Speaking in Tongues - A Neural Snapshot
- The Neural Basis of the Self
- Post-Partum Psychosis - Rare but Real
- Is Your Doctor Happy or Burnt-Out?
- Ginkgo Biloba Ineffective... Again
- Worried Well on the Web
- Psychotropics and Youth, Part 2 - The Solutions
- Why Some Human Brains Become Leaders, While Others Followers?
- Deep Brain Stimulation – A New Frontier in Psychiatry
- Psychotropics and Youth, Part 3 – Equip Teachers with Prescription Pads?
- Why Some Human Brains Become Leaders, While Others Followers?
- Brain Blogger Finalist for Two 2010 Research Blogging Awards in Neuroscience and Psychology
- Tall Tales of Diabetic Amputations
- Psychotropics and Youth, Part 2 – The Solutions
- Brain Blogging, Forty-Ninth Edition
- How Your Brain Groups Words
- The Child Brain and the Playing Teacher
- You Have a Right to Choose if we Agree
- Measuring Quality in Primary Care
- Matchmaker, Matchmaker Make Me A Match – The NRMP Main Residency Match
- Psychotropics and Youth, Part 1 – The Five Myths
- When It Comes to Aging, Size Matters
- “I Feel Your Pain” – The Neural Basis of Empathy
- Speaking in Tongues – A Neural Snapshot
- Neuro Case 1 – Using Transcranial Doppler for Basilar Artery Occlusion
- Journal Retracts Autism Research
- Crossing the Line from Physician to Journalist
- Ginkgo Biloba Ineffective… Again
- Dear Dan,There is certainly much clinical interest in this field. ClinicalTr...
- I recently commented on a sciencedaily.com article reporting success with TRD an...
- I have family members who are teachers. After sharing this article with them, th...
- It is great that people are challenging the use of this medication. As, a societ...
- I agree with the stand of the teachers and their children's that more than half ...
- I think that there’s also a social aspect to it. If you grow up in an area where...
- I have had epilepsy since I was 9 and am now 42. I have tried about every med. o...
- In this text is a serious error. Brain areas are found that contain religious ex...
- It's amazing how the brain works....
- Organ transplant for unavoidable patients have been around for quite some time a...
- Diet plays a major role in having diabetes. In today's world, people are finding...
- Interesting... I think that there's also a social aspect to it. If you grow up i...
- I think the article is actually describing a normal human being. Leadership tra...
- I think that applies to leaders within certain fields of knowledge or creativity...
- Thank you for your comments, Shaheen. Your article was quite interesting and you...
- Dear Bill,I wrote on this issue for ...
- In December we had the findings that suggested we not have mammograms if we are ...
- I agree Bill. They'd like to test children if society allowed it, but it's not "...
- I can "speak in tongues", or babble something that sounds like language, at will...
- Interesting piece. The third point really struck me. So the medical establishmen...
Sponsored Links
Diet and Health Supplements, Best vitamins supplements, Brain Fitness DVD, Home Care, Alcohol Rehab, Emergency Lighting, Online Criminal Justice Degrees, Tattoo, Health Insurance, Electronic Accessory , Rollup Banner Stands , Biotherapeutic Product Information , Metastatic Breast Cancer , Buy Advair Diskus Online , Lung Health , Lung Cancer Treatment , Dallas health insurance agency , Arthritis Treatment , Mail Order Pharmacy , Lung Cancer Treatment , Plano personal injury attorney , How Common Are Treatment Reactions? , Edgepark Medical , Mattress , Hydroxycut, Astrology compatibility.
Neuroscience & Neurology
March 06, 2010 | 5 Comments | By Simi Agarwal, DDS
Why Some Human Brains Become Leaders, While Others Followers?
More In Neuroscience & Neurology
- How Your Brain Groups Words
- The Child Brain and the Playing Teacher
- “I Feel Your Pain” – The Neural Basis of Empathy
- Speaking in Tongues – A Neural Snapshot
- Neuro Case 1 – Using Transcranial Doppler for Basilar Artery Occlusion
Neuroscience & Neurology
Opinion
February 01, 2010 | 1 Comment | By Jennifer Gibson, PharmD
Crossing the Line from Physician to Journalist
More In Opinion
- Sex, Violence and The Male Warrior Hypothesis
- Bruxism and the Brain
- Religion – A “Natural” Phenomenon?
- Natural Good, Chemical Bad – Right?
- Time for a Change – Gender Reassignment
Opinion
Psychiatry & Psychology
March 12, 2010 | 3 Comments | By Shaheen E Lakhan, MS, MEd, PhD, MD
Deep Brain Stimulation – A New Frontier in Psychiatry
More In Psychiatry & Psychology
- Psychotropics and Youth, Part 2 – The Solutions
- Psychotropics and Youth, Part 1 – The Five Myths
- Journal Retracts Autism Research
- White Bears – The Paradox of Mental Suppression
- Sugar and Spice and Everything Nice?


T’aint in Yoor head…the medical deities Always say that for alot of diseases they can’y beat into submission with Drugs.
Alternative medicine has achieved spectacular victories:but it requires a patient change his lifestyle;not an easy way out for sure. Diet,supplements are the key.
Everyone,please check out Rbt Cohen’s website:
http://www.notmilk.com/
and Andrew Saul’s
http://doctoryourself.com/colitis.html