All Articles by Lindsey Kay, MD
Dr. Kay is a medical doctor with training in pathology, and an avid writer. During his training, he worked on pre-clinical and clinical trials in a variety of laboratories related to alcohol effects on the brain, cancer diagnosis, and alternative medicine.
Using Infrared Light to Diagnosis Alzheimer’s
The definitive diagnosis of Alzheimer's disease requires microscopic examination of brain tissue, something that cannot be performed safely in a living patient. Instead, physicians use a constellation of symptoms and patterns of progression, combined with exclusion of all other causes of dementia, to diagnosis patients with the disease. But there are many alternative causes of memory loss in the elderly that must be excluded in order to make the diagnosis of Alzheimer's. Many of these have signs and symptoms that overlap, making it difficult to determine the correct diagnosis.
Interactive Effects of Genetics on Depression
It is well known that depression results from the combination of many different factors. Environmental effects, such as stressful life events, are a trigger in many patients for the development of major depressive disorder (MDD) and the milder disorder, dysthymia. It is also true that the same major stressors will not produce depressive symptoms in some, pointing to underlying risk factors that make some more susceptible to depression than others. Researchers have attempted to identify a single gene that can be linked to MDD, and while familial clustering of depressive disorders is a common finding, single-gene inheritance patterns are not seen. Instead, patterns suggested that several genes are involved in depression, and a recent research study demonstrated the interactive effects of these genes on the disease.
Are You Depressed Because You’re Introverted?
A study published in Psychological Science evaluated the link between happiness and personality traits in 973 twins. The authors found that happiness was heritable, and that it showed genetic linkage to certain personality traits. Those who were extroverted, open, agreeable and conscientious were more likely to be happy. Moreover, twins who exhibited similar personality traits had similar levels of happiness in a seemingly genetic pattern.
A Genetic Susceptibility to PTSD?
Post-traumatic stress disorder (PTSD) has been in the news a lot lately, primarily due to the prevalence of PTSD in Iraq war veterans. PTSD can occur following any severely stressful event, and recent research has shown that some individuals are genetically "at-risk" for its development.A study of adult victims of childhood trauma compared the occurrence of PTSD and genetic variations in the FKBP5 gene, which is related to stress response. Not surprisingly, the study found that both abusive and nonabusive childhood traumatic events were linked to the development of PTSD. In addition, four specific variations of the FKBP5 gene significantly increased the risk of PTSD in child abuse victims. This effect was still present after controlling for depression severity, age, sex, and the occurrence of other kinds of trauma.
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