Teaching the Brain to Calm Itself

Estimates of combat-related Post-Traumatic Stress Disorder (PTSD) in U.S. veterans since the Vietnam War ranges from approximately 2& to 17%. Additional studies of combat veterans of more recent wars places the range of Iraq War returnees who suffer from PTSD  between 4% and 17%. Currently, there is no one form of treatment that has been found effective in combating this disorder, but can the brain somehow be encouraged to calm itself down?

PTSD is classified as an anxiety disorder brought on as the result of witnessing a life-threatening event. The individual repeatedly re-experiences distressing memories of the event and this constant repetition eventually alters the composition of the neural networks which process traumatic memories. This memory repetition also initiates:

  • Iterative learning – learning through repetition to fear the traumatic event
  • Top-down activation – expecting to find a certain pattern, the brain focuses attention on finding evidence of that pattern and not processing what is actually there
  • Pruning – eliminating tiny connections between neurons called synapses that don’t receive a lot of activity, further changing the structure of neural networks

Eventually, the PTSD patient is unable to distinguish between similar experiences. Minor threats to their personal safety are perceived as being on the same level as major ones which causes heightened anxiety responses.

Researchers from the Columbia University Medical Center have been experimenting with activating the dentate gyrus – a part of the hippocampus – to relieve stress in PTSD patients and those with similar anxiety disorders. The researchers inserted light-sensitive proteins called opsins into the dentate gyrus of mice models. They used light from a fiber optic strand to alternately activate and silence both portions of the dentate gyrus for three minute intervals while the mice took part in two anxiety tests.

The researchers found that stimulating the dorsal dentate gyrus – the area involved in learning – caused the mice to be more interested in investigating their surroundings, but it inhibited their ability to learn. However, when they stimulated the ventral portion – which is involved in anxiety – the animals’ anxiety levels were decreased without interfering with their ability to learn new things. The researchers also discovered that the effects could be reversed. When the they stopped activating the dentate gyrus, the mice returned to their previous states of anxiety.

From these results, the researchers concluded that there is potential for alleviating anxiety in individuals with anxiety disorders by targeting the ventral dentate gyrus with medication or deep-brain stimulation. The advantage to this kind of targeted therapy is that it makes an immediate impact on behavior and so it could work much faster than current courses of treatment.


Kheirbek MA, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE, Zeng H, Fenton AA, & Hen R (2013). Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus. Neuron, 77 (5), 955-68 PMID: 23473324

McFarlane AC, Yehuda R, & Clark CR (2002). Biologic models of traumatic memories and post-traumatic stress disorder. The role of neural networks. The Psychiatric clinics of North America, 25 (2) PMID: 12136500

Richardson LK, Frueh BC, & Acierno R (2010). Prevalence estimates of combat-related post-traumatic stress disorder: critical review. The Australian and New Zealand journal of psychiatry, 44 (1), 4-19 PMID: 20073563

Image via Oleg Zabielin / Shutterstock.

  • onergk69

    I am a former medic in the Air Force during Vietnam. I am also a professor & clinician in psychology.

    PTSD is the most severe form of an anxiety spectrum disorder. In war, combatants face repeated terrors & horrors! Neuroimaging shows adverse structural changes to 3 key structures in the limbic or “reactiving brain”. They are the: hippocampus, amygdala, & hypothalamus. In addition to PTSD, many combatants experience Traumatic Brain Injury (TBI). Additionally, the autonmic nervous system is grossly impacted & homeostasis of the sympathetic/parasympathetic branches is severely compromised.

    DBS offers additional hope in dealing w vets in the above circumstances. However, group psychotherapy & EMDR are also known to be efficacious in the long-term tratment.


  • Mark Martins

    Post-Traumatic Stress Disorder (PTSD) is a tough thing to deal with. My grandfather was one of the war veterans(army) fighting for our country against terrorists. He witnessed his friends die and from then, it was really hard for him. He has recurring nightmares brought by the war. I also have made an article about the brain. If you have a time,kindly check it out.
    Just click here:article on brain.

  • Pingback: Weekly Magapsine – S20 | elDronte()

  • My cousin is in the Army and he was deployed in Afghanistan for several years. I think he has this PTSD because I’ve seen him acting differently. He always feels uneasy and gets upset easily. He can’t sleep and he’s taking sleeping pills to help him rest. It’s hard to see him like that. I hope he will go for a treatment.

  • Kim

    It’s difficult for people who have experienced being in combat and coming back to live “normally”. My friend has been in the army for about 2 years, and he’s taking medication to lessen his anxiety.

  • Pingback: Big Changes for Diagnosing PTSD | Brain Blogger()

  • Pingback: Big Changes for Diagnosing PTSD()

Maria Esposito, MA

Maria Esposito, MA, holds a masters of arts in English from Fordhan University. She is now a medical writer who writes patient-oriented articles and blogs based on peer review medical research.

See All Posts By The Author

Do not miss out ever again. Subscribe to get our newsletter delivered to your inbox a few times a month.