Articles Tagged ‘trial’
Drugs & Clinical Trials | By November 15, 2008 | By Jennifer Gibson, PharmD | 1 Comment
How Much is a Pound of Prevention Worth?
The cholesterol-lowering drugs collectively known as “statins” are among the top drugs sold in the United States, and worldwide. Although current guidelines only recommend the use of statins for people with elevated cholesterol, there is new evidence that these recommendations should be expanded. The November 20, 2008 issue of the New England Journal of Medicine will report the findings of the Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER), which were also reported on November 9 at an American Heart Association Conference in New Orleans. The JUPITER trial studied nearly 18,000 healthy adults without high cholesterol and found that daily therapy with rosuvastatin (Crestor) significantly prevented cardiovascular events. Read more →
- Should Doctors be Paid by Drug Companies for Research?
- A Failed Attempt to Improve Perceived Greatness: The ENHANCE Trial
- The Human Injury of Lost Objectivity: An Insider’s Look into the Corruption of Clinical Trials
- Antipsychotic Drug Development off Course?
As research has moved away from the realm of universities and into the private sector, more physicians are being paid by drug companies to enroll and monitor patients during clinical trials. Private corporations have been the largest sponsors of pharmaceutical research in both Canada and the United Sates in the last twenty years.
Research Ethics Boards (REB’s) exist to protect the safety of research subjects. However, they provide guidelines only, and often guidelines are ambiguous. REB’s may be private entities, and thus may be vulnerable to pressure. Read more →
While it seems that sponsors of clinical trials usually end up with results that clearly favor their medicine, there are rare exceptions. Merck and Schering-Plough proved that with their disappointing ENHANCE Trial which many have heard about through the media.
Vytorin is a combination pill for high cholesterol and contains Merck’s Zocor, which is now generic, and Schering’s Zetia, which works differently than Zocor — one of many statin drugs. Read more →
If I were to rate the corruptive tactics performed by big pharmaceutical companies, the intentional corruption of implementing fabricated and unreliable results of clinical trials would be at the top of the list. Pharmaceutical companies manipulate the trials they sponsor because of their power to control others involved in the process largely absent of regulation. This is a matter of requiring authenticity and, more importantly, assuring the safety of the public health. Read more →
Antipsychotic drug development may be off course. Since its accidental discovery during 1951 (Shen 1999), 15 to 40 drugs have been used to treat antipsychotic symptoms. Further developement in drug treatment was on hold until the introduction of Clozapine treatment in the United States in 1990. Discontinuation of antipsychotic medications is common because they don’t work in all patients and because of adverse effects, including metabolic side effects, weight gain and involuntary movements (Tandon 2006). Read more →
Saturday, March 20, 2010
- Religion - A "Natural" Phenomenon?
- Psychotropics and Youth, Part 1 - The Five Myths
- How Culture Shapes Our Mind and Brain
- Sex, Violence and The Male Warrior Hypothesis
- The Secret to Good Health – Listen to the Data
- If Herbal Medicine is Medicine, Shouldn't it be Treated as Such?
- Neurology, Neurosurgery, and Neuroscience Conferences for 2010
- Too Much Information?
- "I Feel Your Pain" - The Neural Basis of Empathy
- Income Inequality and Health Outcomes
- The Evolution of Depression
- Journal Retracts Autism Research
- Speaking in Tongues - A Neural Snapshot
- Post-Partum Psychosis - Rare but Real
- Is Your Doctor Happy or Burnt-Out?
- Ginkgo Biloba Ineffective... Again
- Worried Well on the Web
- Psychotropics and Youth, Part 2 - The Solutions
- Why Some Human Brains Become Leaders, While Others Followers?
- Postoperative Cognitive Dysfunction
- Let the Matches Begin!
- My Nephew and his Brain, Part 4 – Their Life Today
- My Nephew and his Brain, Part 3 – Try to Work Out their Troubles
- My Nephew and his Brain, Part 2 – Revealed to be Complicated
- My Nephew and his Brain, Part 1 – Introduction
- Deep Brain Stimulation – A New Frontier in Psychiatry
- Psychotropics and Youth, Part 3 – Equip Teachers with Prescription Pads?
- Why Some Human Brains Become Leaders, While Others Followers?
- Brain Blogger Finalist for Two 2010 Research Blogging Awards in Neuroscience and Psychology
- Tall Tales of Diabetic Amputations
- Psychotropics and Youth, Part 2 – The Solutions
- Brain Blogging, Forty-Ninth Edition
- How Your Brain Groups Words
- The Child Brain and the Playing Teacher
- You Have a Right to Choose if we Agree
- Measuring Quality in Primary Care
- Matchmaker, Matchmaker Make Me A Match – The NRMP Main Residency Match
- Psychotropics and Youth, Part 1 – The Five Myths
- When It Comes to Aging, Size Matters
- “I Feel Your Pain” – The Neural Basis of Empathy
- Very touching story. My heart goes out to your family. Seizures are tough. And ...
- Thank you for sharing your nephew's story. So hard on those who love him, but I...
- Congratulations to all who've matched! Although the results of NRMP Main Residen...
- It's been almost 25 years since my son suffered a TBI in an accident. He was onl...
- I tend to agree with the teachers.But a teacher can only keep a record about the...
- Very interesting article, the 5th paragraph gets a little biased...but I still e...
- Dear Dan,There is certainly much clinical interest in this field. ClinicalTr...
- I recently commented on a sciencedaily.com article reporting success with TRD an...
- I have family members who are teachers. After sharing this article with them, th...
- It is great that people are challenging the use of this medication. As, a societ...
- I agree with the stand of the teachers and their children's that more than half ...
- I think that there’s also a social aspect to it. If you grow up in an area where...
- I have had epilepsy since I was 9 and am now 42. I have tried about every med. o...
- In this text is a serious error. Brain areas are found that contain religious ex...
- It's amazing how the brain works....
- Organ transplant for unavoidable patients have been around for quite some time a...
- Diet plays a major role in having diabetes. In today's world, people are finding...
- Interesting... I think that there's also a social aspect to it. If you grow up i...
- I think the article is actually describing a normal human being. Leadership tra...
- I think that applies to leaders within certain fields of knowledge or creativity...

