Drugs & Clinical Trials | By March 05, 2009 | By Sajid Surve, DO | 7 Comments

Lithium as a Neuroprotectant?

Lithium is an elemental chemical found naturally as an alkali metal. The ionic form can be used to form salts which are readily available for medicinal purposes. Although the exact mechanism of action for lithium is unknown, it is believed to function by simultaneously raising serotonin levels and lowering norepinephrine levels. Lithium is used primarily as a mood stabilizer, as it has the unique ability to treat both mania and depression. Unfortunately, the downside of lithium is that it has a very narrow therapeutic window, meaning the blood levels which provide benefits are very close to the blood levels which cause side effects and toxicity. Because of the need for such close monitoring of blood levels, the medication has largely fallen out of favor except for certain diseases like bipolar disorder. Read more →