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Drugs & Clinical Trials Topic
Take Two of These… And You Still Might Have Pain
Migraines are severe, often debilitating, headaches that may be accompanied by visual symptoms, as well as nausea and vomiting. Migraines may last up to 24 hours. The exact cause of migraine is unknown, and most treatment focuses on acute pain relief once the migraine begins. For many migraine sufferers, acute pain relief is often ineffective at relieving the migraine symptoms. But, a new analysis published in the Cochrane Database of Systemic Reviews reveals that a single dose of aspirin is effective for more than half of migraine sufferers.
When the Drugs Don’t Work, or Just Make it Worse
When we are given a new prescription, most of us happily go away and take our medicine just like the doctor ordered. We may not study the patient information particularly carefully, and we may not follow the given advice to the letter, but we cheerfully assume that, unless we do something particularly stupid, the medication will do us no harm. But... we could be wrong.
Stimulants May Offer Protection in ADHD
As many as 10% of children suffer from attention deficit-hyperactivity disorder (ADHD), a neuropsychiatric behavioral disorder characterized by inattention, hyperactivity, and impulsivity. ADHD can cause significant functional, social, and psychological impairment in children and adults. ADHD treatment in children has been controversial, since the mainstay of treatment is stimulant medications, including methylphenidate and amphetamines. Parents are appropriately concerned about giving their children powerful medications that can lead to liver damage, addiction to stimulants, or abuse of stimulants or illicit drugs. But, untreated ADHD can have dangerous repercussions, including the development of psychiatric disorders. Now, the benefits might outweigh the risks of stimulant medications as a new study reports that stimulants are actually protective against the development of significant psychiatric disorders associated with ADHD.
One Size Does Not Fit All
Up to half of drug therapy is ineffective, according to recent statistics. This leaves patients’ diseases untreated, but also places them at risk for side effects and drug interactions. The reason for the unpredictability in the effectiveness of medication comes from a variety of factors: individual differences in enzymes that metabolize drugs, variations in drug transporters, ethnic differences, and environmental changes. For decades, the idea of personalized medicine -- assessing and evaluating individual differences to tailor medicine and therapy regimens for the best results -- has brought about new drugs and led to effective treatment of several diseases. However, now clinicians and researchers are returning to old drugs to optimize personalized therapy.
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