Comments on: Topical Morphine – An Experimental Approach to Chronic Pain http://brainblogger.com/2009/02/22/topical-morphine-an-experimental-approach-to-chronic-pain/ Topics from multidimensional biopsychosocial perspectives Mon, 21 May 2012 22:26:26 +0000 hourly 1 By: wendyhttp://brainblogger.com/2009/02/22/topical-morphine-an-experimental-approach-to-chronic-pain/#comment-604604 wendy Sun, 03 Jul 2011 12:28:12 +0000 http://brainblogger.com/?p=2334#comment-604604 my aunt was just given the topical morphine to try from her pain management physician. she had a hip replacement in april of 2010 and has had chronic pain ever since. my aunt also suffers from copd which makes it difficult for her to take opiods that dont interfere with her breathing. she was prescribed this topical morphine for this reason in hopes it wont interfere. anyone with any similar health risks that has found a medicine that works for them is asked to please share their findings. thanks from her concerned niece. you can reach me at lovegill@comcast.net my aunt was just given the topical morphine to try from her pain management physician. she had a hip replacement in april of 2010 and has had chronic pain ever since. my aunt also suffers from copd which makes it difficult for her to take opiods that dont interfere with her breathing. she was prescribed this topical morphine for this reason in hopes it wont interfere. anyone with any similar health risks that has found a medicine that works for them is asked to please share their findings. thanks from her concerned niece. you can reach me at lovegill@comcast.net

]]> By: Irughttp://brainblogger.com/2009/02/22/topical-morphine-an-experimental-approach-to-chronic-pain/#comment-556088 Irug Wed, 05 Aug 2009 21:55:56 +0000 http://brainblogger.com/?p=2334#comment-556088 Living in pain is one of the worst feelings a man or woman can have. I think any experimental approaches on any type of pain killer is a wonderful idea. If the industry took further steps for aiding those with chronic pain i truly feel we could be in a better place in the future. The placebo affect may interfere, but as Jason stated, it is quite unlikely. Living in pain is one of the worst feelings a man or woman can have. I think any experimental approaches on any type of pain killer is a wonderful idea. If the industry took further steps for aiding those with chronic pain i truly feel we could be in a better place in the future. The placebo affect may interfere, but as Jason stated, it is quite unlikely.

]]> By: http://www.kojj.comhttp://brainblogger.com/2009/02/22/topical-morphine-an-experimental-approach-to-chronic-pain/#comment-551487 http://www.kojj.com Tue, 07 Jul 2009 12:33:16 +0000 http://brainblogger.com/?p=2334#comment-551487 <strong>Topical Morphine – An Experimental Approach to Chronic Pain...</strong>Practitioners who treat patients with chronic pain understand just how difficult management of that population can be. As of today, the evaluation of pain remains completely subjective; no lab tests or imaging studies can provide any meaningful insight... Topical Morphine – An Experimental Approach to Chronic Pain…

Practitioners who treat patients with chronic pain understand just how difficult management of that population can be. As of today, the evaluation of pain remains completely subjective; no lab tests or imaging studies can provide any meaningful insight…

]]> By: Jason Victorhttp://brainblogger.com/2009/02/22/topical-morphine-an-experimental-approach-to-chronic-pain/#comment-456905 Jason Victor Sun, 01 Mar 2009 14:11:57 +0000 http://brainblogger.com/?p=2334#comment-456905 Any news on there being larger double-blinded clinical trials for this? It would be interesting to see if there is a placebo effect. It's probably not if no other treatment worked for this population, but still ... Any news on there being larger double-blinded clinical trials for this? It would be interesting to see if there is a placebo effect. It’s probably not if no other treatment worked for this population, but still …

]]> By: Sajid Surve, DOhttp://brainblogger.com/2009/02/22/topical-morphine-an-experimental-approach-to-chronic-pain/#comment-453057 Sajid Surve, DO Thu, 26 Feb 2009 14:30:36 +0000 http://brainblogger.com/?p=2334#comment-453057 Mary,There is a distinct difference between the fentanyl patch and other agents such as the lidocaine and diclofenac patches. Fentanyl is a transdermal agent, while the others are topical agents. Transdermal means it is absorbed through the skin and taken into the bloodstream to work at a site remote from the application site. This is why one can place a fentanyl patch on the chest for low back pain. Topical agents are only meant to act directly under their application site, and have minimal systemic absorption.As for topical morphine, I think its has a possibility to work. If you recall, opioids work by suppressing the release of acetylcholine through binding at the presynaptic mu receptors (peripherally), as well as postsynaptic inhibition of descending efferent pathways (centrally). If this formulation can suppress neuronal activity at the surface nociceptors, then I believe the patients would receive some benefits. Mary,

There is a distinct difference between the fentanyl patch and other agents such as the lidocaine and diclofenac patches. Fentanyl is a transdermal agent, while the others are topical agents. Transdermal means it is absorbed through the skin and taken into the bloodstream to work at a site remote from the application site. This is why one can place a fentanyl patch on the chest for low back pain. Topical agents are only meant to act directly under their application site, and have minimal systemic absorption.

As for topical morphine, I think its has a possibility to work. If you recall, opioids work by suppressing the release of acetylcholine through binding at the presynaptic mu receptors (peripherally), as well as postsynaptic inhibition of descending efferent pathways (centrally). If this formulation can suppress neuronal activity at the surface nociceptors, then I believe the patients would receive some benefits.

]]> By: Mary Scott RPh,CGPhttp://brainblogger.com/2009/02/22/topical-morphine-an-experimental-approach-to-chronic-pain/#comment-453031 Mary Scott RPh,CGP Thu, 26 Feb 2009 13:30:36 +0000 http://brainblogger.com/?p=2334#comment-453031 You neglected to mention a topical opioid, fentanyl (Duragesic), which is used extensively in pain management. It is available in transdermal patch and buccal lozenge.While it has some systemic side-effects like oral opioids, it has been a real godsend for patients with chronic pain. I have been a consultant to various hospice organizations and for patients on multiple oral meds, it really cuts down on the amount of pills they have to swallow per day. Also, it tends to cause more side-effects in those with less muscle stores (use cautiously in 80lb elderly) The topical morphine idea sounds crazy if you ask me-could it be the placebo effect at work? Mary Scott, RPh, CGP (Certified Geriatric Pharmacist) You neglected to mention a topical opioid, fentanyl (Duragesic), which is used extensively in pain management. It is available in transdermal patch and buccal lozenge.While it has some systemic side-effects like oral opioids, it has been a real godsend for patients with chronic pain. I have been a consultant to various hospice organizations and for patients on multiple oral meds, it really cuts down on the amount of pills they have to swallow per day. Also, it tends to cause more side-effects in those with less muscle stores (use cautiously in 80lb elderly)
The topical morphine idea sounds crazy if you ask me-could it be the placebo effect at work?
Mary Scott, RPh, CGP (Certified Geriatric Pharmacist)

]]> By: Prof/Dr Brian Rothbarthttp://brainblogger.com/2009/02/22/topical-morphine-an-experimental-approach-to-chronic-pain/#comment-451534 Prof/Dr Brian Rothbart Wed, 25 Feb 2009 09:45:43 +0000 http://brainblogger.com/?p=2334#comment-451534 Thanks for your post about this very important issue of treatments for chronic pain - a problem of pandemic proportions.Unfortunately, often drugs and means of pain management are the only options offered to chronic pain sufferers. And now with reports of addiction and abuse being rampant in people suffering from pain, it is clear that we need new, permanent and drug free solutions.Having discovered a previously unknown source of chronic musculoskeletal pain after almost 40 years of research and clinical practice, I have developed a therapy that permanently eliminates chronic muscle and joint pain without the use of drugs or surgery.My new book, Forever Free From Chronic Pain discusses not only my discoveries and innovative therapy, but my own experience with chronic pain as well.The book also discusses why current treatments for chronic neck, hip, knee and back pain aren’t working, how to determine if my innovative therapy will work for a chronic pain sufferer and how, through advanced technology, a person’s body can heal itself for good.I invite you to sign up for a free chapter and learn more about my book at: http://www.foreverfreefromchronicpain.com.For those interested in speaking out against the lack of real options for pain sufferers, I invite you to join the group, Citizens for a World Free From Chronic Pain: http://www.facebook.com/inbox/readmessage.php?t=44179172223&mbox_pos=0#/group.php?gid=56453921666&ref=nfThank you for helping to bring awareness to this chronic pain epidemic and the need for real solutions.Best wishes, Prof/Dr Brian A Rothbart Thanks for your post about this very important issue of treatments for chronic pain – a problem of pandemic proportions.

Unfortunately, often drugs and means of pain management are the only options offered to chronic pain sufferers. And now with reports of addiction and abuse being rampant in people suffering from pain, it is clear that we need new, permanent and drug free solutions.

Having discovered a previously unknown source of chronic musculoskeletal pain after almost 40 years of research and clinical practice, I have developed a therapy that permanently eliminates chronic muscle and joint pain without the use of drugs or surgery.

My new book, Forever Free From Chronic Pain discusses not only my discoveries and innovative therapy, but my own experience with chronic pain as well.

The book also discusses why current treatments for chronic neck, hip, knee and back pain aren’t working, how to determine if my innovative therapy will work for a chronic pain sufferer and how, through advanced technology, a person’s body can heal itself for good.

I invite you to sign up for a free chapter and learn more about my book at: http://www.foreverfreefromchronicpain.com.

For those interested in speaking out against the lack of real options for pain sufferers, I invite you to join the group, Citizens for a World Free From Chronic Pain: http://www.facebook.com/inbox/readmessage.php?t=44179172223&mbox_pos=0#/group.php?gid=56453921666&ref=nf

Thank you for helping to bring awareness to this chronic pain epidemic and the need for real solutions.

Best wishes,
Prof/Dr Brian A Rothbart

]]> By: Arthttp://brainblogger.com/2009/02/22/topical-morphine-an-experimental-approach-to-chronic-pain/#comment-449402 Art Mon, 23 Feb 2009 21:19:24 +0000 http://brainblogger.com/?p=2334#comment-449402 Add a bit of DMSO to the morphine mix and it will penetrate deeper and faster. DMSO is a very good carrier agent. Down side is the patients breath will smell like garlic and the DMSO has a smell that reminds me of 'fish tank water'. Add a bit of DMSO to the morphine mix and it will penetrate deeper and faster. DMSO is a very good carrier agent. Down side is the patients breath will smell like garlic and the DMSO has a smell that reminds me of ‘fish tank water’.

]]> By: Katkinkatehttp://brainblogger.com/2009/02/22/topical-morphine-an-experimental-approach-to-chronic-pain/#comment-448049 Katkinkate Sun, 22 Feb 2009 20:07:18 +0000 http://brainblogger.com/?p=2334#comment-448049 I understood that opioids acted on the pain receptors in the brain to kill pain. Am I wrong, or have they just recently discovered they work locally as well? I understood that opioids acted on the pain receptors in the brain to kill pain. Am I wrong, or have they just recently discovered they work locally as well?

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