<?xml version="1.0" encoding="UTF-8"?><rss version="2.0" xmlns:content="http://purl.org/rss/1.0/modules/content/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:atom="http://www.w3.org/2005/Atom" xmlns:sy="http://purl.org/rss/1.0/modules/syndication/" > <channel><title>Comments on: Publication Bias in Reporting Drug Efficacy</title> <atom:link href="http://brainblogger.com/2008/02/18/publication-bias-in-reporting-drug-efficacy/feed/" rel="self" type="application/rss+xml" /><link>http://brainblogger.com/2008/02/18/publication-bias-in-reporting-drug-efficacy/</link> <description>Topics from multidimensional biopsychosocial perspectives.</description> <lastBuildDate>Thu, 18 Mar 2010 21:46:47 +0000</lastBuildDate> <generator>http://wordpress.org/?v=2.9.2</generator> <sy:updatePeriod>hourly</sy:updatePeriod> <sy:updateFrequency>1</sy:updateFrequency> <item><title>By: Why I love the ResearchBlogs twitter feed &#171; info-fetishist</title><link>http://brainblogger.com/2008/02/18/publication-bias-in-reporting-drug-efficacy/#comment-472264</link> <dc:creator>Why I love the ResearchBlogs twitter feed &#171; info-fetishist</dc:creator> <pubDate>Fri, 13 Mar 2009 21:04:33 +0000</pubDate> <guid isPermaLink="false">http://brainblogger.com/2008/02/18/publication-bias-in-reporting-drug-efficacy/#comment-472264</guid> <description>[...] led me as well to a related discussion of this article about publication bias in pharmaceutical research, which sparks more thoughts about information literacy and evaluation.  And this nice summary of [...]</description> <content:encoded><![CDATA[<p>[...] led me as well to a related discussion of this article about publication bias in pharmaceutical research, which sparks more thoughts about information literacy and evaluation.  And this nice summary of [...]</p> ]]></content:encoded> </item> <item><title>By: Dan</title><link>http://brainblogger.com/2008/02/18/publication-bias-in-reporting-drug-efficacy/#comment-101717</link> <dc:creator>Dan</dc:creator> <pubDate>Tue, 11 Mar 2008 21:17:10 +0000</pubDate> <guid isPermaLink="false">http://brainblogger.com/2008/02/18/publication-bias-in-reporting-drug-efficacy/#comment-101717</guid> <description>Pharmaceutical Clinical Trials- the truth about thier creation:A pharma company perhaps has a med awaiting approval.  Criteria for approval is minimal.  Two studies are needed to prove the pending med is better than a placebo.  And this pharma company can do several studies until these two studies are obtained.Now it gets worse, because pharma clinical trials are indeed marketing tools:This company, after thier med is approved, will continue to create trials.  Yes create them.  Hire researchers and control every aspect of any trial they wish, which allows them to embellish such factors as efficacy.  So then these fabrications are complete.  Next step for this pharma company is to approach a medical journal.  Negotiations begin.  The journal agrees to publish this trial which, by the way, was written likely by a ghostwriter, and the name of an author placed on this trial that had absolutely nothing to do with the trial, but still placed his name on this trial because he was paid to do so.  The journal, through dialogue with the pharma company, does in fact publish the trial with the agreement that the pharma company will purchase thousands of copies of the trial from the journal called reprints that the pharma company will distribute to it&#039;s sales reps.  Also, the pharma will agree to pay the journal to advertise its products within it, which is why half of the contents of a medical journal are product plugs.You know, I use to really value science.</description> <content:encoded><![CDATA[<p>Pharmaceutical Clinical Trials- the truth about thier creation:</p><p>A pharma company perhaps has a med awaiting approval.  Criteria for approval is minimal.  Two studies are needed to prove the pending med is better than a placebo.  And this pharma company can do several studies until these two studies are obtained.</p><p>Now it gets worse, because pharma clinical trials are indeed marketing tools:</p><p>This company, after thier med is approved, will continue to create trials.  Yes create them.  Hire researchers and control every aspect of any trial they wish, which allows them to embellish such factors as efficacy.  So then these fabrications are complete.  Next step for this pharma company is to approach a medical journal.  Negotiations begin.  The journal agrees to publish this trial which, by the way, was written likely by a ghostwriter, and the name of an author placed on this trial that had absolutely nothing to do with the trial, but still placed his name on this trial because he was paid to do so.  The journal, through dialogue with the pharma company, does in fact publish the trial with the agreement that the pharma company will purchase thousands of copies of the trial from the journal called reprints that the pharma company will distribute to it&#8217;s sales reps.  Also, the pharma will agree to pay the journal to advertise its products within it, which is why half of the contents of a medical journal are product plugs.</p><p>You know, I use to really value science.</p> ]]></content:encoded> </item> <item><title>By: Science and Prozac &#171; Undergrad Mind</title><link>http://brainblogger.com/2008/02/18/publication-bias-in-reporting-drug-efficacy/#comment-93572</link> <dc:creator>Science and Prozac &#171; Undergrad Mind</dc:creator> <pubDate>Thu, 28 Feb 2008 08:08:13 +0000</pubDate> <guid isPermaLink="false">http://brainblogger.com/2008/02/18/publication-bias-in-reporting-drug-efficacy/#comment-93572</guid> <description>[...] I will leave you with the Publication Bias in Reporting Drug Efficacy and The Supreme Court and the [...]</description> <content:encoded><![CDATA[<p>[...] I will leave you with the Publication Bias in Reporting Drug Efficacy and The Supreme Court and the [...]</p> ]]></content:encoded> </item> <item><title>By: Michael</title><link>http://brainblogger.com/2008/02/18/publication-bias-in-reporting-drug-efficacy/#comment-91907</link> <dc:creator>Michael</dc:creator> <pubDate>Tue, 19 Feb 2008 04:33:30 +0000</pubDate> <guid isPermaLink="false">http://brainblogger.com/2008/02/18/publication-bias-in-reporting-drug-efficacy/#comment-91907</guid> <description>I had talked about this subject previously in &lt;a href=&quot;http://brainstimulant.blogspot.com/2008/01/antidepressant-trial-bias-or-not.html&quot; rel=&quot;nofollow&quot;&gt;my own blog&lt;/a&gt;.  I think the pharmaceutical companies should definitely be more transparent about the trials that don&#039;t show favorable results.  However antidepressant trials are notoriously difficult to run due to the large placebo effect.  So it isn&#039;t too surprising that they were not successful in distinguishing the drug effect in several of those trials.</description> <content:encoded><![CDATA[<p>I had talked about this subject previously in <a href="http://brainstimulant.blogspot.com/2008/01/antidepressant-trial-bias-or-not.html" rel="nofollow">my own blog</a>.  I think the pharmaceutical companies should definitely be more transparent about the trials that don&#8217;t show favorable results.  However antidepressant trials are notoriously difficult to run due to the large placebo effect.  So it isn&#8217;t too surprising that they were not successful in distinguishing the drug effect in several of those trials.</p> ]]></content:encoded> </item> <item><title>By: &#187; Presidents Day roundup Millennial Mind: Helping young adults navigate the world of mental illness</title><link>http://brainblogger.com/2008/02/18/publication-bias-in-reporting-drug-efficacy/#comment-91881</link> <dc:creator>&#187; Presidents Day roundup Millennial Mind: Helping young adults navigate the world of mental illness</dc:creator> <pubDate>Mon, 18 Feb 2008 20:33:17 +0000</pubDate> <guid isPermaLink="false">http://brainblogger.com/2008/02/18/publication-bias-in-reporting-drug-efficacy/#comment-91881</guid> <description>[...] Brain Blogger looks at that notorious New England Journal of Medicine study about &#8220;positive bias&#8221; in [...]</description> <content:encoded><![CDATA[<p>[...] Brain Blogger looks at that notorious New England Journal of Medicine study about &#8220;positive bias&#8221; in [...]</p> ]]></content:encoded> </item> </channel> </rss>
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